The ability of D-dimer, albumin, and D-Dimer/albumin ratio to predict in-hospital mortality and intensive care unit admission in COVID-19 patients admitted to the emergency department.

OBJECTIVES: COVID-19 can also cause multi-organ failure or severe pneumonia. Therefore, new biomarkers are being investigated for rapid diagnosis, early treatment and reduced mortality rates. In this study, D-dimer and albumin were looked at from a different perspective. BACKGROUND: We think that D-dimer/Albumin ratio (DAR), D-dimer and albumin may be parameters that can be used to predict in-hospital mortality and intensive care unit admission in COVID-19 patients. METHODS: The patients included in the study were divided into 2 groups according to their hospitalization status in the service and intensive care unit. These two groups were compared in terms of DAR, other laboratory data and in-hospital mortality. RESULTS: The primary findings we obtained are as follows: (1) DAR and D-dimer values are higher in patients who died in-hospital, and albumin values are lower than those who survived; (2) D-dimer and DAR median values are significantly higher in the intensive care group than in the service group. Albumin was significantly lower in the intensive care group; (3) D-dimer, albumin and DAR predicting in-hospital mortality, respectively: D-Dimer's sensitivity 56 % and specificity 57 %, albumin's sensitivity 70 % and specificity 53 %, DAR's sensitivity 56 %, specificity is 58 %; (4) The parameter with the highest predictive power for intensive care admission is albumin. CONCLUSION: Although albumin had the highest sensitivity values in determining mortality or predicting intensive care admission in our study, we think that D-dimer and DAR may be other parameters to be used to predict intensive care admission and in-hospital mortality (Tab. 5, Fig. 2, Ref. 19) Keywords: COVID-19, albumin, D-dimer, mortality, D-dimer/albumin.

The relationship of lipid profile with severity of disease and mortality in patients with COVID-1.

OBJECTIVES: Serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol may be associated with a poor prognosis in COVID-19 patients. BACKGROUND: We think it may be essential to understand the role of lipids in the pathophysiology of COVID-19. METHODS: One hundred eighty-nine patients admitted to the emergency department between 20th January and 20th February 2021 and later decided to be hospitalized to an inpatient clinic or intensive care unit were included in the study. The patients were determined to be hospitalized to the inpatient clinic or intensive care unit according to the Turkish Ministry of Health COVID-19 guidelines. A demographic information form was established for each patient. RESULTS: The primary findings we have obtained were as follows: (1) CRP, PCT, D-Dimer levels were found to be high, while Albumin, TC, HDL-c, and LDL-c levels were found to be low in critical type patients; (2) CRP, PCT, and D-Dimer levels were higher in the patients who were intubated compared to those who were not intubated. Albumin and HDL levels were low; (3) DH was found to have a significantly negative relationship with TC and HDL-c, and (4) Sensitivity of LDL-c in predicting mortality was found as 69 % and specificity as 70 %. It was observed that patients with low LDL-c levels had higher mortality rates. CONCLUSION: We think that hypocholesterolaemia may be an indicator of the impending danger. Our study examined COVID-19 in terms of lipid metabolism and offers a different perspective on the disease (Tab. 4, Ref. 23). Text in PDF www.elis.sk Keywords: COVID-19, lipid, mortality.